Prevention is pivotal in minimizing the morbidity and mortality associated with NLF GNB bacteremia after SOT. Combination therapy may be beneficial in the treatment of NLF GNB bacteremia to enhance antimicrobial activity, provide synergistic interactions, relieve side effects, and minimize superinfections. Certain factors can predispose SOT recipients to NLF GNB bacteremia, which included previous transplantation, hospital-acquired BSIs, and prior intensive care unit admission. Multi-drug resistant NLF GNB ranged from 9.8% to 12.5% of all NLF GNB causing BSIs among SOT recipients. The present retrospective microbiological study was carried out using isolates and data. coli in clinical material has been described in the literature, which may cause a significant diagnostic challenge. Occurrence of atypical, lactose non-fermenting, biochemically inactive strains of E. The morbidity and mortality rates of bacteremia because of NLF GNB depend on the types of organisms and transplantation. Urinary tract infections (UTIs) are some of the most common infections affecting humans worldwide. Two electronic databases, PUBMED and EMBASE, were searched for relevant literature published up to January 2015, to better understand the characteristics of bacteremia because of NLF GNB.
NLF GNB led to high mortality among SOT recipients with bacteremia and were difficult to treat because of their high drug resistance to commonly used antibiotics. In recent years, a progressive growth in the incidence of bacteremia caused by non-lactose fermenting gram-negative bacilli (NLF GNB) has been observed. Blood stream infections (BSIs) remain as a serious life-threatening condition after solid organ transplant (SOT).
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